CAS No. 1612782-86-1
Batch:
Purity:99.98
Chemical Structure
Check the
UNC2541
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (7S)-7-amino-N-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamide | |
|---|---|---|
| CAS Number | 1612782-86-1 | |
| Molecular Formula |
C24H34FN7O2 |
|
| Molecular Weight (MW) | 471.57 | |
| SMILES | C1CCCNC2=NC=C(C(=N2)NCCCCC(C(=O)NCC1)N)C(=O)NCC3=CC=C(C=C3)F | |
| InChIKey | ONIHBIZGUJZDHG-FQEVSTJZSA-N |
UNC2541 is a potent inhibitor of Mer tyrosine kinase (MerTK) that binds within the ATP-binding pocket of the receptor. It inhibits MerTK autophosphorylation and suppresses downstream cell signaling pathways, including AKT and MAPK. By blocking MerTK activation, UNC2541 inhibits downstream survival signaling, cell proliferation, and oncogenic cellular phenotypes in MERTK-dependent biological models. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
94 mg/mL
(199.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.