CAS No. 1493694-70-4
Batch:
Purity:99.43
Chemical Structure
Check the
UNC2250
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[[2-(butylamino)-5-[5-(morpholin-4-ylmethyl)-2-pyridinyl]pyrimidin-4-yl]amino]cyclohexan-1-ol | |
|---|---|---|
| CAS Number | 1493694-70-4 | |
| Molecular Formula |
C24H36N6O2 |
|
| Molecular Weight (MW) | 440.58 | |
| SMILES | CCCCNC1=NC=C(C(=N1)NC2CCC(CC2)O)C3=NC=C(C=C3)CN4CCOCC4 | |
| InChIKey | HSYSSKFCQHXOBP-UHFFFAOYSA-N |
UNC2250 is a potent and selective receptor tyrosine kinase inhibitor targeting Mer, displaying 160-fold selectivity over Axl and 60-fold selectivity over Tyro3. By inhibiting Mer autophosphorylation, the compound blocks activation of downstream AKT and ERK signaling pathways. This inhibition reduces colony formation, inhibits cell proliferation, and promotes apoptosis in MERTK-dependent cancer cell lines.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
2 mg/mL
(4.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.