CAS No. 1429881-91-3
Batch:
Purity:99.96
Chemical Structure
Check the
UNC2025
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[2-(butylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol | |
|---|---|---|
| CAS Number | 1429881-91-3 | |
| Molecular Formula |
C28H40N6O |
|
| Molecular Weight (MW) | 476.66 | |
| SMILES | CCCCNC1=NC=C2C(=CN(C2=N1)C3CCC(CC3)O)C4=CC=C(C=C4)CN5CCN(CC5)C | |
| InChIKey | MJSHVHLADKXCML-UHFFFAOYSA-N |
UNC2025 is a potent and orally active dual inhibitor targeting FLT3 and MER (MERTK) receptor tyrosine kinases. By suppressing FLT3 and MER kinase activity, UNC2025 blocks downstream activation of the STAT, AKT, and ERK signaling pathways. This pathway inhibition leads to decreased cell viability, suppression of colony formation, and induction of apoptosis in acute myeloid leukemia and other receptor tyrosine kinase-dependent tumor models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(209.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 60 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.