CAS No. 1238673-32-9
Batch:
Purity:95.12
Chemical Structure
Check the
UNC0321
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 7-[2-[2-(dimethylamino)ethoxy]ethoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine | |
|---|---|---|
| CAS Number | 1238673-32-9 | |
| Molecular Formula |
C27H45N7O3 |
|
| Molecular Weight (MW) | 515.69 | |
| InChIKey | AULLUGALUBVBDD-UHFFFAOYSA-N |
UNC0321 is a potent and selective inhibitor of G9a histone methyltransferase and G9a-like protein (GLP). By blocking the enzymatic activity of G9a and GLP, UNC0321 reduces histone H3 lysine 9 dimethylation, altering gene transcription and chromatin organization. This target engagement modulates epigenetic signaling pathways, resulting in anti-apoptotic responses and cellular phenotypic changes. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(193.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | 12 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.