CAS No. 1184136-10-4
Batch:
Purity:99.06
Chemical Structure
Check the
UNC-926
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (3-bromophenyl)-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone | |
|---|---|---|
| CAS Number | 1184136-10-4 | |
| Molecular Formula |
C16H21BrN2O |
|
| Molecular Weight (MW) | 337.25 | |
| SMILES | C1CCN(C1)C2CCN(CC2)C(=O)C3=CC(=CC=C3)Br | |
| InChIKey | OWGLFIKZKQOYHZ-UHFFFAOYSA-N |
Biological Activity
UNC-926 is a chemical probe and inhibitor targeting the malignant brain tumor (MBT) domain of L3MBTL1 (Kd 3.9 μM). By selectively occupying the methyl-lysine binding pocket within the MBT repeats, UNC-926 disrupts the interaction between L3MBTL1 and mono- or dimethylated histone lysine residues. This inhibition impairs L3MBTL1-mediated chromatin compaction and transcriptional repression, providing a valuable tool for investigating epigenetic regulation and chromatin biology. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
67 mg/mL
(198.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.