CAS No. 1031602-63-7
Batch:
Purity:99.53
Chemical Structure
Check the
UNC 3230
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-anilino-5-(cyclohexanecarbonylamino)-1,3-thiazole-4-carboxamide | |
|---|---|---|
| CAS Number | 1031602-63-7 | |
| Molecular Formula |
C₁₇H₂₀N₄O₂S |
|
| Molecular Weight (MW) | 344.43 | |
| InChIKey | RZCNASHHHSKTGP-UHFFFAOYSA-N |
UNCis a potent, ATP-competitive inhibitor of phosphatidylinositol-phosphate-kinase type 1C (PIPK1C). Suppression of PIPK1C by UNClowers membrane phosphatidylinositol,-bisphosphate (PIP2) levels in dorsal root ganglion neurons, thereby attenuating nociceptive signaling and hypersensitivity. Furthermore, UNCblocks PIPK1C activity to impair downstream PIK/Akt/mTOR signaling, downregulating aerobic glycolysis and inhibiting tumor growth in colorectal cancer cells. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
69 mg/mL
(200.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.