CAS No. 518303-20-3
| IUPAC Name | 2-[4-[(4-bromophenyl)sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acid | |
|---|---|---|
| CAS Number | 518303-20-3 | |
| Molecular Formula |
C18H14BrNO5S2 |
|
| Molecular Weight (MW) | 468.34 | |
| SMILES | C1=CC=C2C(=C1)C(=CC(=C2O)SCC(=O)O)NS(=O)(=O)C3=CC=C(C=C3)Br | |
| InChIKey | WUGANDSUVKXMEC-UHFFFAOYSA-N |
UMI-77 is a selective inhibitor of Mcl-1 (Ki 490 nM) with selectivity over other Bcl-2 family protein members. By binding to Mcl-1, it disrupts the interaction between Mcl-1 and pro-apoptotic BH3-only proteins as well as Bax and Bak. This inhibition releases Bax and Bak to promote mitochondrial outer membrane permeabilization, triggering cytochrome c release, caspase activation, and apoptosis in cancer cells, particularly pancreatic carcinoma cells. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
93 mg/mL
(198.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 93 mg/mL |
| Water | Insoluble |
| DMSO |
93 mg/mL
(198.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 93 mg/mL |
| Water | Insoluble |
| DMSO |
93 mg/mL
(198.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 93 mg/mL |
| Water | Insoluble |
| DMSO |
93 mg/mL
(198.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 93 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.