CAS No. 903564-48-7
| IUPAC Name | 2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-N-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]phenyl]-1,3-thiazole-5-carboxamide | |
|---|---|---|
| CAS Number | 903564-48-7 | |
| Molecular Formula |
C30H31F3N8O3S |
|
| Molecular Weight (MW) | 640.68 | |
| SMILES | CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)NC(=O)C3=CN=C(S3)NC4=CC(=NC(=N4)C)N5CCN(CC5)CCO | |
| InChIKey | ANEBQUSWQAQFQB-UHFFFAOYSA-N |
UM-164 is a potent dual c-Src and p38 MAP kinase inhibitor that targets c-Src as well as p38α and p38β isoforms. By concurrently blocking c-Src tyrosine kinase activity and p38 MAP kinase signaling cascades, the compound effectively suppresses downstream pro-survival and proliferative pathways. This dual inhibition disrupts key cellular phenotypes, resulting in suppressed cancer cell proliferation, reduced migratory potential, and impaired tumor cell survival. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(156.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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