CAS No. 1591823-76-5
Batch:
Purity:99.02
Chemical Structure
Check the
Ulonivirine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 3-chloro-5-[6-oxo-1-[[6-oxo-5-(trifluoromethyl)-1H-pyridazin-3-yl]methyl]-4-(trifluoromethyl)pyrimidin-5-yl]oxybenzonitrile | |
|---|---|---|
| CAS Number | 1591823-76-5 | |
| Molecular Formula |
C18H8ClF6N5O3 |
|
| Molecular Weight (MW) | 491.73 | |
| InChIKey | YSFHLBYWQCLYIY-UHFFFAOYSA-N |
Biological Activity
Ulonivirine (MK-8507) is a selective non-nucleoside reverse transcriptase inhibitor (NNRTI) that targets HIV-1 reverse transcriptase by binding to the adjacent hydrophobic pocket near the polymerase active site [1]. This allosteric binding induces conformational changes in the enzyme, suppressing viral reverse transcription and inhibiting HIV-1 replication [1, 2]. Additionally, ulonivirine exhibits potential to induce CYP3A4 gene expression, influencing hepatic drug metabolism pathways.[1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
98 mg/mL
(199.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.