CAS No. 1956366-10-1
Batch:
Purity:98.56
Chemical Structure
Check the
Ulixertinib hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1956366-10-1 | |
|---|---|---|
| Molecular Formula |
C21H22Cl2N4O2.ClH |
|
| Molecular Weight (MW) | 469.79 |
Ulixertinib hydrochloride is a potent, highly selective, and ATP-competitive inhibitor targeting extracellular signal-regulated kinases 1 and 2 (ERK1/2). By directly inhibiting ERK1/2 catalytic activity, the compound disrupts the MAPK/ERK signaling cascade, suppressing downstream substrate phosphorylation. Consequently, this pathway inhibition impairs tumor cell proliferation, survival, and growth in various MAPK pathway-mutant cancer models. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
94 mg/mL
(200.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.