CAS No. 2414349-93-0
Batch:
Purity:99.06
Chemical Structure
Check the
UGT8-IN-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [1-[3-(methylcarbamoyl)-7-(trifluoromethyl)thieno[3,2-b]pyridin-5-yl]piperidin-4-yl] N-[(2S)-1-(trifluoromethoxy)propan-2-yl]carbamate | |
|---|---|---|
| CAS Number | 2414349-93-0 | |
| Molecular Formula |
C20H22F6N4O4S |
|
| Molecular Weight (MW) | 528.47 | |
| InChIKey | UQQUABVWYAPTIQ-JTQLQIEISA-N |
UGT8-IN-1 is a brain-penetrable and orally bioavailable inhibitor of ceramide galactosyltransferase (UGT8). The compound targets sulfatide metabolism to induce ceramide-mediated lethal mitophagy and subsequent cancer cell death in vitro. Through this mechanism, UGT8-IN-1 effectively suppresses tumor growth in vivo within mutant Kras; Gnas allograft models, highlighting its potential in targeting oncogenic metabolic vulnerabilities.
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(189.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(189.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.