CAS No. 268203-93-6
Batch:
Purity:99.99
Chemical Structure
Check the
Udenafil
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,5-d]pyrimidin-5-yl)-N-[2-(1-methylpyrrolidin-2-yl)ethyl]-4-propoxybenzenesulfonamide | |
|---|---|---|
| CAS Number | 268203-93-6 | |
| Molecular Formula |
C25H36N6O4S |
|
| Molecular Weight (MW) | 516.66 | |
| SMILES | CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)NCCC4CCCN4C)OCCC)C | |
| InChIKey | IYFNEFQTYQPVOC-UHFFFAOYSA-N |
Udenafil is a potent antagonist of human phosphodiesterase 5 (PDE5) with a selectivity profile comparable to sildenafil. By inhibiting PDE5 activity, it blocks the hydrolytic degradation of cyclic guanosine monophosphate (cGMP), leading to intracellular cGMP accumulation. This elevation in cGMP potentiates nitric oxide-dependent signaling, ultimately promoting vascular smooth muscle relaxation and downstream vasodilatory phenotypes. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(193.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.