CAS No. 339303-87-6
Batch:
Purity:99.93
Chemical Structure
Check the
UCLA GP130 2
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 339303-87-6 | |
|---|---|---|
| Molecular Formula |
C15H11FN2S |
|
| Molecular Weight (MW) | 270.32 | |
| SMILES | FC1=CC=C(NC2=NC(=CS2)C3=CC=CC=C3)C=C1 |
UCLA GP130 2 is a brain-penetrant and orally active glycoprotein 130 (GP130) receptor agonist that acts as a humanin peptide mimetic binding to the GP130 D-Ddomain. By activating GP130 receptor signaling, UCLA GP130 2 attenuates NMDA-induced excitotoxicity and promotes neuronal cell survival. This activation modulates downstream neuroprotective cellular pathways, mitigating neurotoxicity and preserving primary neuronal viability against excitotoxic insults. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
54 mg/mL
(199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 27 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.