CAS No. 2919575-27-0

Batch: Purity:99.65
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UCL-TRO-1938 Chemical Structure
Chemical Structure
Check the UCL-TRO-1938 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[7-[[2-[4-(4-ethylpiperazin-1-yl)anilino]-4-pyridinyl]amino]-2,3-dihydroindol-1-yl]ethanone
CAS Number 2919575-27-0
Molecular Formula

C27H32N6O
Molecular Weight (MW) 456.58
InChIKey RPOHONUDGBSZDK-UHFFFAOYSA-N

Biological Activity

UCL-TRO-1938 is a potent allosteric activator of phosphoinositide 3-kinase alpha (PI3Kα). It enhances PI3Kα catalytic activity and activates downstream AKT/mTOR signaling to stimulate cellular responses including cell proliferation and neurite outgrowth. Through transient activation of the PI3K pathway, UCL-TRO-1938 protects tissues from ischemia-reperfusion injury to provide cardioprotection and promotes nerve regeneration following peripheral injury. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 23 mg/mL (50.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Gong GQ, et al. Nature. 2023;618(7963):159-168.

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Note: Technical data last updated: Sep 1, 2026.