CAS No. 112648-68-7
Batch:
Purity:99.22
Chemical Structure
Check the
U-73122
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[6-[[(8R,9S,13S,14S,17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]amino]hexyl]pyrrole-2,5-dione | |
|---|---|---|
| CAS Number | 112648-68-7 | |
| Molecular Formula |
C29H40N2O3 |
|
| Molecular Weight (MW) | 464.64 | |
| SMILES | CC12CCC3C(C1CCC2NCCCCCCN4C(=O)C=CC4=O)CCC5=C3C=CC(=C5)OC | |
| InChIKey | LUFAORPFSVMJIW-ZRJUGLEFSA-N |
U-73122 is a potent phospholipase C (PLC) inhibitor. It suppresses agonist-induced intracellular Ca2+ elevation and cell aggregation in human platelets and polymorphonuclear neutrophils (PMNs). By blocking PLC-mediated phosphoinositide hydrolysis, U-73122 impairs downstream calcium signaling pathways, neutrophil activation, and inflammatory mediator release, serving as a valuable tool for investigating lipid signaling mechanisms in cellular models. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
93 mg/mL
(200.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMF | 24 mg/mL |
| DMSO |
0.01 mg/mL
(0.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.