CAS No. 142878-12-4
Batch:
Purity:97.65
Chemical Structure
Check the
U-73343
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[6-[[(8R,9S,13S,14S,17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]amino]hexyl]pyrrolidine-2,5-dione | |
|---|---|---|
| CAS Number | 142878-12-4 | |
| Molecular Formula |
C29H42N2O3 |
|
| Molecular Weight (MW) | 466.66 | |
| InChIKey | CJHWFIUASFBCKN-ZRJUGLEFSA-N |
U-73343 is an aminosteroid derivative and inactive analog of U-73122 that acts downstream of phospholipase C without inhibiting its enzymatic activity. In cellular models, U-73343 inhibits receptor-mediated phospholipase D activation and modulates lipid second messenger signaling. Additionally, U-73343 acts as an agonist of nuclear estrogen receptors alpha and beta, driving estrogen receptor-dependent transcriptional activity and downstream cellular responses. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
7 mg/mL
(15.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.