CAS No. 168835-90-3
Batch:
Purity:99.76
Chemical Structure
Check the
Tyrphostin AG1433
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-(6,7-dimethylquinoxalin-2-yl)benzene-1,2-diol | |
|---|---|---|
| CAS Number | 168835-90-3 | |
| Molecular Formula |
C16H14N2O2 |
|
| Molecular Weight (MW) | 266.30 | |
| SMILES | CC1=CC2=NC=C(N=C2C=C1C)C3=CC(=C(C=C3)O)O | |
| InChIKey | SMKFYHOKXJUJOT-UHFFFAOYSA-N |
Biological Activity
Tyrphostin AG1433 is a selective inhibitor of platelet-derived growth factor receptor β (PDGFRβ) and vascular endothelial growth factor receptor 2 (VEGFR-2). By suppressing receptor tyrosine kinase autophosphorylation, this compound disrupts downstream growth factor-mediated receptor signaling pathways. Consequently, Tyrphostin AG1433 impairs growth factor-stimulated cell proliferation and cell migration, ultimately inhibiting vascular endothelial cell activation and tumor angiogenesis. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
53 mg/mL
(199.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.