CAS No. 148741-30-4
| IUPAC Name | (E)-2-cyano-3-(3,5-ditert-butyl-4-hydroxyphenyl)prop-2-enethioamide | |
|---|---|---|
| CAS Number | 148741-30-4 | |
| Molecular Formula |
C18H24N2OS |
|
| Molecular Weight (MW) | 316.46 | |
| SMILES | CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C=C(C#N)C(=S)N | |
| InChIKey | XRZYELWZLNAXGE-KPKJPENVSA-N |
Tyrphostin AG 879 is a potent tyrosine kinase inhibitor targeting HER2/ErbB2 with selective activity over PDGFR and EGFR. By suppressing HER2 receptor autophosphorylation, AG 879 effectively disrupts downstream intracellular signaling cascades, including the MAPK and AKT pathways. Consequently, inhibition of this receptor tyrosine kinase leads to reduced cell proliferation, G1 cell cycle arrest, and the induction of apoptosis in HER2-overexpressing cancer cells. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
36 mg/mL
(113.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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