CAS No. 133550-49-9
Batch:
Purity:99.86
Chemical Structure
Check the
Tyrphostin AG-528
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (E)-2-(2,3-dihydroindole-1-carbonyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile | |
|---|---|---|
| CAS Number | 133550-49-9 | |
| Molecular Formula |
C18H14N2O3 |
|
| Molecular Weight (MW) | 306.32 | |
| SMILES | C1CN(C2=CC=CC=C21)C(=O)C(=CC3=CC(=C(C=C3)O)O)C#N | |
| InChIKey | MYKCTDWWIWGLHW-NTEUORMPSA-N |
Tyrphostin AG-528 is a small-molecule inhibitor targeting epidermal growth factor receptor (EGFR) and ErbB2/HER2 receptor tyrosine kinases. By blocking EGFR and ErbB2/HER2 kinase activity, it suppresses downstream receptor autophosphorylation and inhibits cell proliferation signaling mediated by the MAPK and AKT/mTOR pathways. Consequently, Tyrphostin AG-528 exhibits significant anticancer activity by impairing cancer cell growth and survival. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
61 mg/mL
(199.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | ˂1 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.