CAS No. 146535-11-7

Batch: Purity:99.90
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Tyrphostin AG 1296 Chemical Structure
Chemical Structure
Check the Tyrphostin AG 1296 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6,7-dimethoxy-2-phenylquinoxaline
CAS Number 146535-11-7
Molecular Formula

C16H14N2O2
Molecular Weight (MW) 266.29
SMILES COC1=C(C=C2C(=C1)N=CC(=N2)C3=CC=CC=C3)OC
InChIKey QNOXYUNHIGOWNY-UHFFFAOYSA-N

Biological Activity

Tyrphostin AG 1296 is a selective receptor tyrosine kinase inhibitor targeting platelet-derived growth factor receptor (PDGFR). By inhibiting PDGFR autophosphorylation, Tyrphostin AG 1296 suppresses downstream Ras/MAPK and PI3K/AKT signaling pathways, leading to suppressed cell proliferation, migration, and survival. Furthermore, blockade of these signaling networks induces cell cycle arrest and promotes apoptosis in transformed and tumor cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 6 mg/mL (22.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Kovalenko M, et al. Cancer Res. 1994;54(23):6106-14.

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Note: Technical data last updated: Sep 1, 2026.