CAS No. 2823289-77-4
Chemical Structure
Check the
TYRA-200
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[1-[5-fluoro-2-[[1-(2-hydroxy-2-methylpropyl)pyrazol-4-yl]amino]pyrimidin-4-yl]-3-methylindol-5-yl]prop-2-enamide | |
|---|---|---|
| CAS Number | 2823289-77-4 | |
| Molecular Formula |
C23H24FN7O2 |
|
| Molecular Weight (MW) | 449.48 | |
| InChIKey | IMSVRBNZOZXJLS-UHFFFAOYSA-N |
TYRA-200 is an orally bioavailable inhibitor of fibroblast growth factor receptors 1, 2, and 3 (FGFR1/2/3). By targeting FGFR kinase activity, it blocks downstream activation of the MAPK and AKT/mTOR pathways. This inhibition suppresses tumor cell proliferation and survival in FGFR-driven cancer models, effectively addressing resistance mediated by FGFR2 gatekeeper and molecular brake mutations. [1][2]
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Note: Technical data last updated: Sep 1, 2026.