CAS No. 934369-14-9
Chemical Structure
Check the
TY-52156
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 934369-14-9 | |
|---|---|---|
| Molecular Formula |
C18H19Cl2N3O |
|
| Molecular Weight (MW) | 364.27 | |
| SMILES | ClC1=CC=C(/N=C(NNC2=CC=C(Cl)C=C2)/C(C(C)(C)C)=O)C=C1 |
TY-52156 is a selective antagonist of the sphingosine-1-phosphate receptor 3 (S1P3) with a Ki of 110 nM. By inhibiting S1P3-mediated signaling pathways, TY-52156 suppresses S1P-induced intracellular calcium mobilization and vascular smooth muscle cell contraction. Downstream, this targeted inhibition prevents S1P-dependent coronary artery constriction and attenuates inflammatory cellular phenotypes associated with S1P3 receptor activation.
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Note: Technical data last updated: Sep 1, 2026.