CAS No. 104012-37-5
Batch:
Purity:99.84
Chemical Structure
Check the
Tussilagone
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 104012-37-5 | |
|---|---|---|
| Molecular Formula |
C23H34O5 |
|
| Molecular Weight (MW) | 390.51 | |
| SMILES | CCC(=CC(=O)OC1CC(C2C(C1=C)CC(=O)C2C(C)OC(=O)C)C(C)C)C |
Tussilagone is a natural sesquiterpenoid isolated from Tussilago farfara that exhibits potent anti-inflammatory activity. It inhibits lipopolysaccharide-induced inflammatory cascades by suppressing the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Downstream, tussilagone blocks NF-kB activation and reduces the production of pro-inflammatory mediators including nitric oxide and prostaglandin E2, attenuating inflammatory responses in cellular models.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
78 mg/mL
(199.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
77 mg/mL
(197.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.