CAS No. 2567686-02-4

Batch: Purity:99.00
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Tulmimetostat (CPI-0209) Chemical Structure
Chemical Structure
Check the Tulmimetostat (CPI-0209) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2R)-7-chloro-2-[4-(3-methoxyazetidin-1-yl)cyclohexyl]-2,4-dimethyl-N-[(6-methyl-4-methylsulfanyl-2-oxo-1H-pyridin-3-yl)methyl]-1,3-benzodioxole-5-carboxamide
CAS Number 2567686-02-4
Molecular Formula

C28H36ClN3O5S
Molecular Weight (MW) 562.12
InChIKey CAAWBLRXQXMGHV-WOLMIXIISA-N

Ordering Information

Biological Activity

Tulmimetostat (CPI- is a potent, orally bioavailable inhibitor of enhancer of zeste homolog 2 (EZH2). By targeting the catalytic subunit of Polycomb repressive complex 2 (PRC2), tulmimetostat suppresses global histone H3 lysine 27 trimethylation (H3K27me3) and alters transcriptional programs. These molecular changes impair tumor growth and enhance chemosensitivity to agents such as cisplatin, showing marked activity in ARID1A-mutant preclinical cancer models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (177.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 50 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.