CAS No. 1616493-44-7
Batch:
Purity:99.99
Chemical Structure
Check the
Tucidinostat (Chidamide)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-(2-amino-4-fluorophenyl)-4-[[[(E)-3-pyridin-3-ylprop-2-enoyl]amino]methyl]benzamide | |
|---|---|---|
| CAS Number | 1616493-44-7 | |
| Molecular Formula |
C22H19FN4O2 |
|
| Molecular Weight (MW) | 390.41 | |
| SMILES | C1=CC(=CN=C1)C=CC(=O)NCC2=CC=C(C=C2)C(=O)NC3=C(C=C(C=C3)F)N | |
| InChIKey | SZMJVTADHFNAIS-BJMVGYQFSA-N |
Tucidinostat (Chidamide) is a selective histone deacetylase (HDAC) inhibitor targeting HDAC1 (IC50 95 nM), HDAC2 (IC50 160 nM), HDAC3 (IC50 67 nM), and HDAC10 (IC50 78 nM). It blocks HDAC enzymatic activity, inducing chromatin remodeling and histone hyperacetylation. Downstream, this inhibition promotes G1 phase cell cycle arrest, triggers tumor cell apoptosis, and enhances immune cell-mediated cytotoxicity.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
78 mg/mL
(199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 1 mg/mL |
| Water | Insoluble |
| DMSO |
78 mg/mL
(199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
78 mg/mL
(199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
| DMSO |
78 mg/mL
(199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
78 mg/mL
(199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Tucidinostat (Chidamide) Mechanism of Action: HDAC Inhibition in Lymphocyte Research
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- Tucidinostat (Chidamide): Selectivity & Specificity
- Tucidinostat (Chidamide) Working Concentration | Cell Culture | Treatment
- Tucidinostat (Chidamide) Solubility in DMSO
- Tucidinostat (Chidamide) Stock Solution
- Tucidinostat (Chidamide) Storage
- Tucidinostat (Chidamide) Stability
- Tucidinostat (Chidamide) Combination Database
- Tucidinostat (Chidamide) Molecular Weight
- Tucidinostat (Chidamide) SMILES
- Tucidinostat (Chidamide) Chemical Structure (2D and 3D)
- Tucidinostat (Chidamide) IC50 for Cell-based and Cell-free Assays
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Note: Technical data last updated: Sep 1, 2026.