CAS No. 6879-01-2

Batch: Purity:100.00
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Tuberostemonine Chemical Structure
Chemical Structure
Check the Tuberostemonine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 6879-01-2
Molecular Formula

C22H33NO4
Molecular Weight (MW) 375.50
SMILES CCC1C2CCCCN3C2C(CC3C4CC(C(=O)O4)C)C5C1OC(=O)C5C

Biological Activity

Tuberostemonine is a natural alkaloid isolated from Stemona species that functions as an anti-inflammatory and antitussive agent. It suppresses the production of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6, by inhibiting activation of the NF-kB and MAPK signaling pathways. Consequently, tuberostemonine mitigates inflammatory responses and attenuates cellular injury in tissue models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 75 mg/mL (199.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 75 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Phytomedicine. 2003;10:5.

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Note: Technical data last updated: Sep 1, 2026.