CAS No. 1357920-84-3

Batch: Purity:99.95
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Belizatinib (TSR-011) Chemical Structure
Chemical Structure
Check the Belizatinib (TSR-011) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-fluoro-N-[6-[[4-(2-hydroxypropan-2-yl)piperidin-1-yl]methyl]-1-[4-(propan-2-ylcarbamoyl)cyclohexyl]benzimidazol-2-yl]benzamide
CAS Number 1357920-84-3
Molecular Formula

C33H44FN5O3
Molecular Weight (MW) 577.73
SMILES CC(C)NC(=O)C1CCC(CC1)N2C3=C(C=CC(=C3)CN4CCC(CC4)C(C)(C)O)N=C2NC(=O)C5=CC=C(C=C5)F
InChIKey WSTUJEXAPHIEIM-UHFFFAOYSA-N

Biological Activity

Belizatinib (TSR-011) is a potent dual inhibitor of anaplastic lymphoma kinase (ALK) and tropomyosin receptor kinase (TRK) family proteins, including TRKA, TRKB, and TRKC. By blocking ATP-binding sites within these receptor tyrosine kinases, it suppresses downstream activation of key signaling pathways such as MAPK/ERK and PI3K/AKT. This targeted inhibition leads to impaired cellular proliferation and induction of apoptosis in cancer cells driven by oncogenic ALK or TRK alterations. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (173.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Cocco E, et al. Nat Rev Clin Oncol. 2018;15(12):731-747.

[2] Lin JJ, et al. Cancer Discov. 2017;7(2):137-155.

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Note: Technical data last updated: Sep 1, 2026.