CAS No. 58880-19-6

Batch: Purity:99.53
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Trichostatin A (TSA) Chemical Structure
Chemical Structure
Check the Trichostatin A (TSA) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide
CAS Number 58880-19-6
Molecular Formula

C17H22N2O3
Molecular Weight (MW) 302.4
SMILES CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
InChIKey RTKIYFITIVXBLE-QEQCGCAPSA-N

Ordering Information

Biological Activity

Trichostatin A (TSA) is an antifungal antibiotic and broad-spectrum histone deacetylase (HDAC) inhibitor with an IC50 of ~in cell-free assays. By inhibiting HDAC enzymes, TSA promotes histone hyperacetylation, which modulates chromatin structure and gene transcription. This HDAC inhibition leads to cell cycle arrest, cell differentiation, and apoptosis across various mammalian cell types and cancer cell lines. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 23 mg/mL (76.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.