CAS No. 58880-19-6
Batch:
Purity:99.94
Chemical Structure
Check the
Trichostatin A (TSA)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide | |
|---|---|---|
| CAS Number | 58880-19-6 | |
| Molecular Formula |
C17H22N2O3 |
|
| Molecular Weight (MW) | 302.4 | |
| SMILES | CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C | |
| InChIKey | RTKIYFITIVXBLE-QEQCGCAPSA-N |
Biological Activity
Trichostatin A (TSA) is an antifungal antibiotic and broad-spectrum histone deacetylase (HDAC) inhibitor with an IC50 of ~in cell-free assays. By inhibiting HDAC enzymes, TSA promotes histone hyperacetylation, which modulates chromatin structure and gene transcription. This HDAC inhibition leads to cell cycle arrest, cell differentiation, and apoptosis across various mammalian cell types and cancer cell lines. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
60 mg/mL
(198.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
Jump to
- Trichostatin A (TSA) Mechanism of Action: HDAC Inhibition in Cancer Cell Research
- Trichostatin A (TSA) Clinical Trials
- Trichostatin A (TSA) Working Concentration | Cell Culture | Treatment
- Trichostatin A (TSA) Solubility in DMSO
- Trichostatin A (TSA) Stock Solution
- Trichostatin A (TSA) Storage
- Trichostatin A (TSA) Stability
- Trichostatin A (TSA) Combination Database
- Trichostatin A (TSA) Molecular Weight
- Trichostatin A (TSA) SMILES
- Trichostatin A (TSA) Chemical Structure (2D and 3D)
- Trichostatin A (TSA) IC50 for Cell-based and Cell-free Assays
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Note: Technical data last updated: Sep 1, 2026.