CAS No. 13220-57-0
Batch:
Purity:99.94
Chemical Structure
Check the
Tryptanthrin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 13220-57-0 | |
|---|---|---|
| Molecular Formula |
C15H8N2O2 |
|
| Molecular Weight (MW) | 248.24 | |
| SMILES | C1=CC=C2C(=C1)C(=O)N3C4=CC=CC=C4C(=O)C3=N2 |
Biological Activity
Tryptanthrin is a natural indoloquinazoline alkaloid that acts as an anti-inflammatory and antitumor agent. It suppresses inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression, reducing nitric oxide and prostaglandin production. Downstream, tryptanthrin modulates NF-kB and MAPK signaling pathways, leading to inhibition of cell proliferation, suppression of inflammatory responses, and induction of apoptosis in cancer cells. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
8 mg/mL
(32.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.