CAS No. 259674-19-6
Batch:
Purity:98.42
Chemical Structure
Check the
TRPM8 antagonist 2
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | methyl (2S)-2-(dibenzylamino)-3-(1H-indol-3-yl)propanoate | |
|---|---|---|
| CAS Number | 259674-19-6 | |
| Molecular Formula |
C26H26N2O2 |
|
| Molecular Weight (MW) | 398.50 | |
| SMILES | COC(=O)C(CC1=CNC2=CC=CC=C21)N(CC3=CC=CC=C3)CC4=CC=CC=C4 | |
| InChIKey | HHVOOJDLCVOLKI-VWLOTQADSA-N |
TRPM8 antagonist 2 is a potent and selective antagonist of transient receptor potential melastatin 8 (TRPM8). By inhibiting TRPM8-mediated calcium influx, this agent blocks cold- and menthol-activated channel signaling in sensory neurons. The suppression of TRPM8 channel activation dampens downstream nociceptive signaling pathways, thereby attenuating cold hypersensitivity and cold allodynia associated with neuropathic pain syndromes. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
80 mg/mL
(200.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 22 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.