CAS No. 97322-87-7

Batch: Purity:99.47
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Troglitazone (CS-045) Chemical Structure
Chemical Structure
Check the Troglitazone (CS-045) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
CAS Number 97322-87-7
Molecular Formula

C24H27NO5S
Molecular Weight (MW) 441.54
SMILES CC1=C(C2=C(CCC(O2)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C(=C1O)C)C
InChIKey GXPHKUHSUJUWKP-UHFFFAOYSA-N

Biological Activity

Troglitazone is a potent agonist of peroxisome proliferator-activated receptor gamma (PPARγ), a ligand-activated transcription factor involved in lipid metabolism and cell differentiation. Activation of PPARγ signaling modulates downstream gene transcription to regulate cellular differentiation and growth. In cancer cell models, troglitazone induces autophagy, apoptosis, and necroptosis, while also suppressing lipid peroxidation to inhibit RSL3-induced ferroptosis. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 88 mg/mL (199.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 15 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Lehmann JM, et al. J Biol Chem. 1995;270(22):12953-6.

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Note: Technical data last updated: Sep 1, 2026.