CAS No. 74285-86-2

Batch: Purity:99.72
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Triptophenolide Chemical Structure
Chemical Structure
Check the Triptophenolide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 74285-86-2
Molecular Formula

C20H24O3
Molecular Weight (MW) 312.40
SMILES CC(C)C1=C(C2=C(C=C1)C3(CCC4=C(C3CC2)COC4=O)C)O

Biological Activity

Triptophenolide is a natural product derived from Tripterygium wilfordii that acts as a potent pan-antagonist of wild-type and mutant androgen receptors (AR). By blocking androgen receptor activation across diverse mutant variants, it suppresses AR nuclear translocation and downstream transcriptional activity. This targeted inhibition disrupts androgen receptor signaling pathways, leading to inhibited cell proliferation and induced apoptosis in prostate cancer models. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 62 mg/mL (198.46 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Watson PA, et al. Nat Rev Cancer. 2015;15(12):701-11.

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Note: Technical data last updated: Sep 1, 2026.