CAS No. 6138-79-0

Batch: Purity:99.92
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Triprolidine Hydrochloride Chemical Structure
Chemical Structure
Check the Triprolidine Hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 6138-79-0
Molecular Formula

C19H22N2.HCl.H2O
Molecular Weight (MW) 332.87
SMILES CC1=CC=C(C=C1)C(=CCN2CCCC2)C3=CC=CC=N3.O.Cl

Biological Activity

Triprolidine hydrochloride is a first-generation histamine H1 receptor antagonist. By selectively binding to and blocking histamine H1 receptors, it suppresses histamine-mediated signaling pathways and downregulates G-protein-coupled receptor activation. This competitive inhibition prevents downstream intracellular calcium mobilization, thereby reducing vascular permeability, smooth muscle contraction, and tissue inflammation associated with allergic hypersensitivity responses. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 62 mg/mL (186.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Hill SJ, et al. Pharmacol Rev. 1997;49(3):253-78.

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Note: Technical data last updated: Sep 1, 2026.