CAS No. 62637-93-8

Batch: Purity:99.24
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Trimethylamine N-oxide dihydrate Chemical Structure
Chemical Structure
Check the Trimethylamine N-oxide dihydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 62637-93-8
Molecular Formula

C3H13NO3
Molecular Weight (MW) 111.14
SMILES C[N+](C)(C)[O-].O.O

Ordering Information

Biological Activity

Trimethylamine N-oxide dihydrate (TMAO dihydrate) is an organic osmolyte and protein stabilizer that counteracts the destabilizing effects of urea on protein structure. As a naturally occurring gut microbiota-derived metabolite, TMAO promotes protein folding and structural stability by enhancing hydrophobic interactions and altering peptide backbone hydration. Elevated TMAO levels influence cellular stress responses and promote pro-inflammatory signal transduction pathways, contributing to vascular dysfunction and cardiovascular pathogenesis. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 22 mg/mL (197.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.