CAS No. 23256-42-0
Batch:
Purity:99.19
Chemical Structure
Check the
Trimethoprim (lactate)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-hydroxypropanoic acid;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine | |
|---|---|---|
| CAS Number | 23256-42-0 | |
| Molecular Formula |
C14H18N4O3.C3H6O3 |
|
| Molecular Weight (MW) | 380.40 | |
| InChIKey | IIZVTUWSIKTFKO-UHFFFAOYSA-N |
Trimethoprim (lactate) is an antifolate antibacterial agent that selectively inhibits bacterial dihydrofolate reductase (DHFR). By competitive inhibition of DHFR, it disrupts the conversion of dihydrofolic acid to tetrahydrofolic acid, an essential cofactor required for purine, pyrimidine, and amino acid biosynthesis. Consequently, inhibition of this bacterial folate pathway impairs bacterial DNA replication and RNA and protein synthesis, resulting in bacteriostatic activity against susceptible microorganisms. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
76 mg/mL
(199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 36.5 mg/mL (超声加热五分钟 ) |
| Ethanol | 12 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.