CAS No. 4192-90-9
Batch:
Purity:99.32
Chemical Structure
Check the
Trilobatin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[2,6-dihydroxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-hydroxyphenyl)propan-1-one | |
|---|---|---|
| CAS Number | 4192-90-9 | |
| Molecular Formula |
C21H24O10 |
|
| Molecular Weight (MW) | 436.41 | |
| SMILES | C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)OC3C(C(C(C(O3)CO)O)O)O)O)O | |
| InChIKey | GSTCPEBQYSOEHV-QNDFHXLGSA-N |
Trilobatin is a natural flavonoid molecule that functions as an HIV-1 entry inhibitor targeting the HIV-1 envelope glycoprotein gp41. It exhibits marked antioxidant and anti-inflammatory properties through modulation of cellular signaling cascades, including suppression of the NF-κB pathway and attenuation of oxidative stress. Downstream effects include reduced production of pro-inflammatory cytokines and reactive oxygen species, suppressing cellular injury and inflammatory damage.
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
87 mg/mL
(199.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
10 mg/mL
(22.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.