CAS No. 1098-60-8

Batch: Purity:99
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Triflupromazine hydrochloride Chemical Structure
Chemical Structure
Check the Triflupromazine hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine;hydrochloride
CAS Number 1098-60-8
Molecular Formula

C18H20ClF3N2S
Molecular Weight (MW) 388.88
SMILES CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)C(F)(F)F.Cl
InChIKey FTNWXGFYRHWUKG-UHFFFAOYSA-N

Biological Activity

Triflupromazine hydrochloride is a phenothiazine-class antipsychotic that acts primarily as an antagonist of dopamine receptors, particularly dopamine D2 receptors. By blocking central dopamine D2 receptor signaling, it suppresses dopaminergic neurotransmission in mesolimbic pathways. This antagonism inhibits downstream G-protein-coupled receptor signaling, leading to modulated neuronal excitability, attenuated hyperdopaminergic responses, and neuroleptic phenotypic effects in cellular and animal models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 78 mg/mL (200.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.