CAS No. 38260-01-4

Batch: Purity:99
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Triethylenetetramine 2HCl Chemical Structure
Chemical Structure
Check the Triethylenetetramine 2HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine;dihydrochloride
CAS Number 38260-01-4
Molecular Formula

C6H20Cl2N4
Molecular Weight (MW) 219.16
SMILES C(CNCCNCCN)N.Cl.Cl
InChIKey WYHIICXRPHEJKI-UHFFFAOYSA-N

Biological Activity

Triethylenetetramine 2HCl is a copper(II)-selective chelator widely investigated for the treatment of Wilson's disease and oncology applications. By binding intracellular copper ions, it reduces systemic bioavailable copper levels, leading to the inhibition of copper-dependent angiogenic signaling and enzymatic processes. Consequently, copper depletion by triethylenetetramine suppresses tumor growth and angiogenesis while inducing cell cycle arrest and apoptosis in cancer models.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 44 mg/mL
DMSO 15 mg/mL (68.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.