CAS No. 3117940-39-0
Batch:
Purity:99.91
Chemical Structure
Check the
TRI-611
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 3117940-39-0 | |
|---|---|---|
| Molecular Formula |
C21H16N4O5 |
|
| Molecular Weight (MW) | 404.38 |
TRI-611 is a brain-penetrant molecular glue degrader of anaplastic lymphoma kinase (ALK) fusion proteins. By recruiting cereblon (CRBN) to a distal degron, it promotes polyubiquitination and proteasomal degradation of both wild-type and TKI-refractory ALK. Downstream, ALK degradation suppresses oncogenic signaling pathways, leading to the inhibition of cellular proliferation and inducing tumor regressions in ALK-positive non-small cell lung cancer models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
20 mg/mL
(49.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
81 mg/mL
(200.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.