CAS No. 299-75-2
Batch:
Purity:98.97
Chemical Structure
Check the
Treosulfan
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 299-75-2 | |
|---|---|---|
| Molecular Formula |
C6H14O8S2 |
|
| Molecular Weight (MW) | 278.30 | |
| SMILES | C[S](=O)(=O)OCC(O)C(O)CO[S](C)(=O)=O |
Treosulfan is a prodrug of a bifunctional alkylating agent that acts by targeting genomic DNA. Under physiological conditions, it converts non-enzymatically into active epoxide intermediates that form DNA interstrand cross-links, thereby inhibiting DNA replication and transcription. This alkylating mechanism triggers cell cycle arrest and apoptosis, resulting in potent cytotoxic activity against pancreatic cancer cell lines.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
56 mg/mL
(201.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 56 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.