CAS No. 141136-83-6
Batch:
Purity:98.76
Chemical Structure
Check the
TRAP-6
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-oxobutanoic acid | |
|---|---|---|
| CAS Number | 141136-83-6 | |
| Molecular Formula |
C34H56N10O9 |
|
| Molecular Weight (MW) | 748.87 | |
| InChIKey | HAGOWCONESKMDW-FRSCJGFNSA-N |
TRAP-6 is a synthetic hexapeptide that acts as an agonist of protease-activated receptor-1 (PAR-1) and activates G-protein coupled receptor 15 (GPR15) on T-cells. Activation of GPR15 by TRAP-6 promotes β-arrestin2 interactions to inhibit TAK1 and NF-κB signaling pathways. This pathway regulation suppresses acute graft-versus-host disease (GvHD) while maintaining graft-versus-tumor (GvT) responses and regulating immune responses. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(133.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 25 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.