CAS No. 1896-62-4

Batch: Purity:99.43
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Trans-4-Phenyl-3-buten-2-one Chemical Structure
Chemical Structure
Check the Trans-4-Phenyl-3-buten-2-one product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (E)-4-phenylbut-3-en-2-one
CAS Number 1896-62-4
Molecular Formula

C10H10O
Molecular Weight (MW) 146.19
SMILES CC(=O)/C=C/C1=CC=CC=C1
InChIKey BWHOZHOGCMHOBV-BQYQJAHWSA-N

Ordering Information

Biological Activity

Trans-4-Phenyl-3-buten-2-one is a small-molecule inhibitor of the enzyme phospholipase A2 (PLA2). By directly inhibiting PLA2 activity, it blocks the liberation of arachidonic acid and disrupts downstream lipid mediator signaling pathways. This cellular inhibition leads to suppressed eicosanoid biosynthesis and impaired immune responses, while also demonstrating antibacterial properties as a natural bacterial metabolite.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 29 mg/mL (198.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 29 mg/mL
Ethanol 29 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.