CAS No. 2271119-26-5

Batch: Purity:99.98
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Elzovantinib (TPX-0022) Chemical Structure
Chemical Structure
Check the Elzovantinib (TPX-0022) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (11S)-16-amino-2-ethyl-6-fluoro-11-methyl-14-oxo-10-oxa-2,13,17,18,21-pentazatetracyclo[13.5.2.04,9.018,22]docosa-1(21),4(9),5,7,15(22),16,19-heptaene-5-carbonitrile
CAS Number 2271119-26-5
Molecular Formula

C20H20FN7O2
Molecular Weight (MW) 409.42
InChIKey UUDPUQDMSHQSKH-NSHDSACASA-N

Biological Activity

Elzovantinib (TPX-0022) is a potent, orally bioavailable multi-kinase inhibitor targeting MET, CSF1R, and SRC. By suppressing MET and SRC signaling, it disrupts downstream RAS/MAPK and PI3K/AKT pathways to inhibit tumor cell proliferation, migration, and survival. Concurrently, CSF1R inhibition modulates the tumor immune microenvironment by depleting immunosuppressive tumor-associated macrophages, resulting in potent dual direct anti-tumor and immunomodulatory activity in preclinical cancer models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Ethanol 5 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Gherardi E, et al. Nat Rev Cancer. 2012;12(2):89-103.

[2] Cannarile MA, et al. J Immunother Cancer. 2017;5(1):53.

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Note: Technical data last updated: Sep 1, 2026.