CAS No. 1222780-33-7
Batch:
Purity:99.43
Chemical Structure
Check the
TPPU
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea | |
|---|---|---|
| CAS Number | 1222780-33-7 | |
| Molecular Formula |
C16H20F3N3O3 |
|
| Molecular Weight (MW) | 359.34 | |
| SMILES | CCC(=O)N1CCC(CC1)NC(=O)NC2=CC=C(OC(F)(F)F)C=C2 | |
| InChIKey | AAJMQTLFRTZCJK-UHFFFAOYSA-N |
TPPU is a potent soluble epoxide hydrolase (sEH) inhibitor targeting human sEH and monkey sEH. By preventing the enzymatic hydrolysis of endogenous epoxyeicosatrienoic acids into inactive diols, TPPU stabilizes anti-inflammatory lipid mediators. This elevation of protective oxylipins attenuates NF-kB pathway activation, suppressing downstream inflammatory signaling, fibrotic remodeling, and tissue damage in preclinical models of chronic inflammatory and cardiovascular diseases. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
72 mg/mL
(200.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 36 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.