CAS No. 79756-69-7
Batch:
Purity:99.72
Chemical Structure
Check the
TPI-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione | |
|---|---|---|
| CAS Number | 79756-69-7 | |
| Molecular Formula |
C12H6Cl2O2 |
|
| Molecular Weight (MW) | 253.08 | |
| SMILES | C1=CC(=C(C=C1Cl)C2=CC(=O)C=CC2=O)Cl | |
| InChIKey | ZKHFYORNAYYOTM-UHFFFAOYSA-N |
TPI-1 is a potent small-molecule inhibitor of Src homology region 2 domain-containing phosphatase-1 (SHP-1). By suppressing SHP-1 activity, it modulates protein tyrosine phosphorylation and key downstream signaling cascades, including the STAT3 pathway. This pathway modulation promotes immune cell activation and impairs oncogenic signaling, leading to inhibition of tumor growth and robust anticancer activity in various cancer models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
51 mg/mL
(201.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.