CAS No. 2490276-04-3
Batch:
Purity:99.08
Chemical Structure
Check the
TP-1454
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[(2-amino-6-fluorophenyl)methyl]-N-[2-(1,1-dioxothian-4-yl)ethyl]-5-(trifluoromethyl)-1H-pyrazole-3-carboxamide | |
|---|---|---|
| CAS Number | 2490276-04-3 | |
| Molecular Formula |
C19H22F4N4O3S |
|
| Molecular Weight (MW) | 462.46 | |
| InChIKey | GASMZUDGPKMAEI-UHFFFAOYSA-N |
TP-1454 is a small-molecule activator of pyruvate kinase M2 (PKM2). As a key rate-limiting enzyme in the glycolytic pathway, PKM2 functions as a central metabolic regulator of cellular energy. Pharmacological activation of PKM2 by TP-1454 modulates downstream cellular metabolism, macrophage polarization, and T-cell regulation, demonstrating pleiotropic therapeutic properties across metabolic and inflammatory disease contexts. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
92 mg/mL
(198.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.