CAS No. 1341200-45-0

Batch: Purity:99.95
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Dubermatinib(TP-0903) Chemical Structure
Chemical Structure
Check the Dubermatinib(TP-0903) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[[5-chloro-2-[4-[(4-methylpiperazin-1-yl)methyl]anilino]pyrimidin-4-yl]amino]-N,N-dimethylbenzenesulfonamide
CAS Number 1341200-45-0
Molecular Formula

C24H30ClN7O2S
Molecular Weight (MW) 516.06
SMILES CN1CCN(CC1)CC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)N(C)C)Cl
InChIKey YUAALFPUEOYPNX-UHFFFAOYSA-N

Biological Activity

Dubermatinib (TP-0903) is a small-molecule, potent, and selective AXL receptor tyrosine kinase inhibitor. By targeted inhibition of AXL, the compound blocks receptor autophosphorylation and disrupts key downstream signaling cascades, including the AKT and ERK pathways. Consequently, this target blockade impairs cell survival, reverses epithelial-mesenchymal transition phenotype, and robustly induces apoptotic cell death in targeted cancer cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 3 mg/mL (5.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol 2 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] mat. 2015;29(2):377-378.

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Note: Technical data last updated: Sep 1, 2026.