CAS No. 2080306-20-1

Batch: Purity:99.60
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TP-064 Chemical Structure
Chemical Structure
Check the TP-064 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-methyl-N-[[2-[1-[2-(methylamino)ethyl]piperidin-4-yl]-4-pyridinyl]methyl]-3-phenoxybenzamide
CAS Number 2080306-20-1
Molecular Formula

C28H34N4O2
Molecular Weight (MW) 458.60
SMILES CNCCN1CCC(CC1)C2=NC=CC(=C2)CN(C)C(=O)C3=CC(=CC=C3)OC4=CC=CC=C4
InChIKey VUIITYLFSAXKIQ-UHFFFAOYSA-N

Biological Activity

TP-064 is a potent, selective inhibitor of protein arginine methyltransferase 4 (PRMT4, IC50 < 10 nM) with over-fold selectivity over other PRMT family proteins. It reduces arginine dimethylation of cellular PRMT4 substrates, including BAF155 (IC50 = 340 nM) and MED12 (IC50 = 43 nM). Consequently, TP-064 suppresses cell proliferation and promotes G1-phase cell cycle arrest in multiple myeloma cell lines. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 92 mg/mL (200.61 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 92 mg/mL
Ethanol 92 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Nakayama K, et al. Oncotarget. 2018;9(26):18480-18493.

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Note: Technical data last updated: Sep 1, 2026.