CAS No. 606-58-6
Batch:
Purity:99.90
Chemical Structure
Check the
Toyocamycin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile | |
|---|---|---|
| CAS Number | 606-58-6 | |
| Molecular Formula |
C12H13N5O4 |
|
| Molecular Weight (MW) | 291.26 | |
| InChIKey | XOKJUSAYZUAMGJ-WOUKDFQISA-N |
Toyocamycin is an adenosine analog that acts as an inhibitor of XBP1 mRNA splicing and a specific inhibitor of CDK9 (IC50 79 nM). Blockade of the IRE1α/XBP1 pathway impairs endoplasmic reticulum stress responses and promotes apoptosis in cancer cells, whereas CDK9 inhibition suppresses RNA polymerase II phosphorylation to reactivate epigenetically silenced tumor suppressor genes.[1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
58 mg/mL
(199.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
58 mg/mL
(199.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.