CAS No. 100490-36-6
Batch:
Purity:99.73
Chemical Structure
Check the
Tosufloxacin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 100490-36-6 | |
|---|---|---|
| Molecular Formula |
C19H15F3N4O3 |
|
| Molecular Weight (MW) | 404.34 |
Biological Activity
Tosufloxacin (A-61827) is an orally active fluoroquinolone antibiotic that targets bacterial DNA gyrase and topoisomerase IV. By inhibiting these essential enzymes, it impairs DNA replication and transcription, leading to potent bactericidal activity against a broad spectrum of Gram-positive and Gram-negative bacteria. Tosufloxacin displays broad antibacterial efficacy in various bacterial infection models. [1]
How to Prepare Stock Solution?
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Concentration
Volume
Mass
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|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.